Alzheimer's disease : recent findings in pathophysiology, diagnostic and therapeutic modalities /

Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.

Библиографические подробности
Другие авторы: Govindaraju, Thimmaiah (Редактор)
Формат: Licensed eBooks
Язык:английский
Опубликовано: Cambridge, UK : Royal Society of Chemistry, 2022.
Online-ссылка:https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=3138942
Оглавление:
  • Intro
  • Title
  • Copyright
  • Contents
  • Chapter 1 Alzheimer's is a Multifactorial Disease
  • 1.1 Introduction
  • 1.2 Pathological Events
  • 1.2.1 Amyloid Burden
  • 1.2.2 Tau Toxicity
  • 1.2.3 Metal Ion Toxicity
  • 1.2.4 Oxidative Stress
  • 1.2.5 Biomolecule Damage
  • 1.2.6 Membrane Toxicity
  • 1.2.7 Calcium Dyshomeostasis
  • 1.2.8 Role of Cholesterol
  • 1.2.9 Mitochondrial Dysfunction
  • 1.2.10 Endoplasmic Reticulum Stress
  • 1.2.11 Impairment in Telomerase Activity
  • 1.2.12 Cholinergic Toxicity
  • 1.2.13 Synaptic Dysfunction
  • 1.2.14 Immune Outrage
  • 1.2.15 Neurovascular Toxicity
  • 2.3.2 When Amyloid Plaque Dysfunctions Together With Tau Pathology That Results in Havoc
  • 2.3.3 Other Cellular Mishaps That Converge in the Anomaly of Homeostasis
  • 2.4 Genetics as a Promising Tool for Alzheimer's Disease
  • References
  • Chapter 3 Alzheimer's Disease Pathology: A Tau Perspective
  • 3.1 Tau and Alzheimer's Disease
  • 3.1.1 Alzheimer's Disease
  • 3.2 Conclusions
  • 3.3 Future Perspectives for Small Molecules As Tau Therapeutics
  • References

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