Biomaterial Based Approaches to Study the Tumour Microenvironment /

This book provides an introduction to the rich chemical, topographical, and mechanical cues in the tumour microenvironment and then introduces readers to bioengineering strategies.

Bibliographic Details
Other Authors: Winter, Jessica (Chemical engineer), Rao, Shreyas
Format: Licensed eBooks
Language:English
Published: Cambridge : Royal Society of Chemistry, 2022.
Series:Biomaterials science series.
Online Access:https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=3487865
Table of Contents:
  • Cover
  • Contents
  • Preface
  • Chapter 1 Tissue Engineering Models for Cancer Pathology
  • 1.1 Introduction
  • 1.2 Historical Timeline
  • 1.3 Content Organization
  • 1.4 Conclusions and Future Outlook
  • Acknowledgements
  • References
  • Chapter 2 Introduction to the Tumor Microenvironment
  • 2.1 Cancer
  • 2.2 The Tumor Microenvironment
  • 2.3 The Tumor and its Microenvironment
  • Principles
  • 2.4 The Phenotype of TME-residing Cells (Cancer andNon-cancerous Cells Alike) is Shaped by Reciprocal Cues
  • 2.4.1 Cell to Cell Signaling
  • 2.4.2 Acellular Signaling
  • 2.5 Target Cancer-TME Interactions for Cancer Therapy
  • Acknowledgements
  • References
  • Chapter 3 Mimicking Fibrous Topographical Features of the Tumor Microenvironment
  • 3.1 The Fibrous Extracellular Matrix in Tumors
  • 3.2 Strategies to Mimic Fibrous ECM
  • 3.3 Capturing the Interactions in the Tumor Microenvironment
  • 3.3.1 Protrusions in Cancer Cells
  • 3.3.2 Cancer Cell Migration
  • 3.3.3 Forces Exerted by Cancer Cells
  • 3.4 Concluding Remarks
  • Acknowledgements
  • References
  • Chapter 4 Mimicking Mechanical Features of the Tumor Microenvironment
  • 4.1 Introduction to the Complex Nature of the Cancer Microenvironment
  • 4.2 Impact of the Tumor MicroenvironmentalComponents or Constituents on Mechanics (Three Ways)
  • 4.3 Microenvironmental Embedded Cells Impact Mechanics
  • 4.3.1 Endothelial Cells Including Tumor Endothelial Cells and Pericytes
  • 4.3.2 Cancer Associated Fibroblasts (CAFs)
  • 4.3.3 Mast Cells in Tumors
  • 4.3.4 Tumor Associated Macrophages (TAMs)
  • 4.3.5 Immune Cells of the Innate and Adaptive Immune System
  • 4.3.6 Cancer-associated Eosinophiles
  • 4.3.7 Cancer-associated Neutrophiles
  • 4.4 Dimensionality of Cell Culture Systems and Mechanics
  • 4.5 How Can the Mechanics of Tumor Microenvironments be Mimicked?
  • 4.6 Effects of Native and Synthetic Microenvironments on Matrix and Cancer Cell Mechanics
  • 4.6.1 Synthetic Matrices
  • 4.6.2 Combined Native and Synthetic Matrices
  • 4.6.3 Interpenetrating Networks
  • 4.6.4 Microstructured Gels
  • 4.7 Multicomponent Tumor Microenvironment Models
  • 4.8 How do Mechanical Phenotypes of TumorMicroenvironments Contribute to Malignant Cancer Progression?
  • 4.9 Conclusion and Outlook
  • References
  • Chapter 5 Mimicking Chemical Features of the Tumor Microenvironment
  • 5.1 Introduction
  • 5.2 Hallmarks of the Tumor Microenvironment
  • 5.2.1 Components of the Tumor Microenvironment
  • 5.3 Biomaterial Strategies to Mimic the Tumor Microenvironment
  • 5.3.1 Natural Biomaterials
  • 5.3.2 Synthetic Biomaterials
  • 5.4 Recent Advances in Biomaterial Design for Cancer Research
  • 5.5 Conclusion
  • Disclosure Statement
  • Abbreviations
  • Acknowledgements
  • References
  • Chapter 6 Mimicking Multicellular Features of the Tumor Microenvironment
  • 6.1 Introduction
  • 6.1.1 Basic Concepts for Modelling the Tumour Microenvironment

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