The origin of chirality in the molecules of life : from awareness to current theories and perspectives of this unsolved problem /

This book provides an interdisciplinary review of one of the great unsolved mysteries that has fascinated scientists for over 150 years: the origin of chirality in biomolecules. It is fundamental, comprehensive and structured to be accessible for educational purposes.

Detalhes bibliográficos
Autor principal: Guijarro, Albert (Author)
Formato: Licensed eBooks
Idioma:inglês
Publicado em: Cambridge : Royal Society of Chemistry, 2022.
Edição:Second edition.
Acesso em linha:https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=3308369
Sumário:
  • Intro
  • Title
  • Copyright
  • Contents
  • Chapter 1 Introduction and Historical Background
  • 1.1 Introduction
  • 1.2 The Contribution of Pasteur
  • 1.2.1 Quartz
  • 1.2.2 Tartaric Acid and the Tartrates
  • 1.3 The Nature of the Problem
  • References
  • Chapter 2 The Concept of Chirality
  • 2.1 Introduction
  • 2.2 The First Absolute Stereochemical Determination of a Molecule, Again Tartaric Acid
  • 2.2.1 X-Ray Crystallography to Determine Absolute Configuration
  • 2.2.2 Chiroptical Methods of Absolute Determination
  • 2.3 Molecular Symmetry and Chirality
  • 2.3.1 Symmetry Elements
  • 2.3.2 Point Groups
  • 2.4 True and False Chirality
  • 2.5 The Discrete Symmetry Operators
  • 2.5.1 The Space Inversion: The Parity Operator, P̂
  • 2.5.2 The Time Reversion: The Time Reversal Operator, T̂
  • 2.5.3 The Charge Conjugation: The Charge Conjugation Operator, Ĉ
  • 2.6 The Failure of the Experiments of Pasteur, Curie and Others: Experiments in the Absence of Chirality and Experiments Under the Influence of False or True Chirality
  • 2.6.1 Experiments in the Absence of a Chiral Field
  • 2.6.2 Experiments Under False Chiral Influence
  • 2.6.3 Experiments Under True Chiral Influence
  • 2.7 Expected Effect of True and False Chirality on Molecules
  • 2.8 Quantum Mechanical Treatment of Molecular Chirality
  • References
  • Chapter 3 Theories of the Origin of Biomolecular Homochirality
  • 3.1 Introduction
  • 3.2 Chance Theories
  • 3.2.1 Amplification of Tiny Stochastic Imbalances
  • 3.2.2 Polymerizations Above a Critical Chain Length: Macromolecules
  • 3.3 Deterministic Theories
  • References
  • Chapter 4 Chiral Physical Forces
  • 4.1 Background
  • 4.2 The Weak Interaction and the Parity Violation
  • 5.2.2 Theoretical Models Derived from Frank's Original Model
  • 5.2.3 Attempts Looking for Autocatalytic Amplification of the Weak Force
  • 5.2.4 Amplification of Chirality in Chemical Reactions
  • 5.2.5 Self-replication
  • 5.3 Amplification of Chirality by Cooperative Forces: Growing Polymers and Supramolecular Assemblies
  • 5.3.1 Amplification of Chirality in Polymerization
  • 5.3.2 Amplification of Chirality in Supramolecular Assemblies
  • 5.4 The Yamagata Cumulative Mechanism
  • 5.5 The Salam Phase Transition
  • 5.6 Amplification of Scalemic Compounds: Eutectic Mixtures

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