Alzheimer's disease : recent findings in pathophysiology, diagnostic and therapeutic modalities /
Handbook on Alzheimer's disease from aetiology and neurochemistry to diagnostic and therapeutic approaches. Intended to provide an introduction to all aspects of the disease.
| Tác giả khác: | |
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| Định dạng: | Licensed eBooks |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Cambridge, UK :
Royal Society of Chemistry,
2022.
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| Truy cập trực tuyến: | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=3138942 |
Mục lục:
- Intro
- Title
- Copyright
- Contents
- Chapter 1 Alzheimer's is a Multifactorial Disease
- 1.1 Introduction
- 1.2 Pathological Events
- 1.2.1 Amyloid Burden
- 1.2.2 Tau Toxicity
- 1.2.3 Metal Ion Toxicity
- 1.2.4 Oxidative Stress
- 1.2.5 Biomolecule Damage
- 1.2.6 Membrane Toxicity
- 1.2.7 Calcium Dyshomeostasis
- 1.2.8 Role of Cholesterol
- 1.2.9 Mitochondrial Dysfunction
- 1.2.10 Endoplasmic Reticulum Stress
- 1.2.11 Impairment in Telomerase Activity
- 1.2.12 Cholinergic Toxicity
- 1.2.13 Synaptic Dysfunction
- 1.2.14 Immune Outrage
- 1.2.15 Neurovascular Toxicity
- 2.3.2 When Amyloid Plaque Dysfunctions Together With Tau Pathology That Results in Havoc
- 2.3.3 Other Cellular Mishaps That Converge in the Anomaly of Homeostasis
- 2.4 Genetics as a Promising Tool for Alzheimer's Disease
- References
- Chapter 3 Alzheimer's Disease Pathology: A Tau Perspective
- 3.1 Tau and Alzheimer's Disease
- 3.1.1 Alzheimer's Disease
- 3.2 Conclusions
- 3.3 Future Perspectives for Small Molecules As Tau Therapeutics
- References