DNA Photodamage : From Light Absorption to Cellular Responses and Skin Cancer.

Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research.

Podrobná bibliografie
Další autoři: Improta, Roberto, Douki, Thierry
Médium: Licensed eBooks
Jazyk:angličtina
Vydáno: Cambridge : Royal Society of Chemistry, [2022]
Edice:ISSN.
On-line přístup:https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=3117509
Obsah:
  • Intro
  • Half Title
  • Series Title
  • Title
  • Copyright
  • Contents
  • Preface
  • Chapter 1 Photoinduced Processes in DNA: Basic Theoretical and Experimental Features 1
  • 1.1 Introduction
  • 1.2 A Theoretical Basis
  • 1.3 Notion of Spectrum in Photobiology
  • 1.3.1 Emission Spectrum of the Light Source
  • 1.3.2 Absorption Spectrum
  • 1.3.3 Action Spectrum
  • 1.4 A Basic Introduction to Pump-probe Spectroscopies
  • 1.5 Analytical Tools for the Detection of DNA Damage
  • 1.5.1 Antibody-based Assays
  • 1.5.2 Electrophoresis-based Assays
  • 1.5.3 Chromatography-based Assays
  • 1.6 Basic Biological Phenomena Associated with DNA Damage
  • 1.6.1 From DNA Damage to Abnormal Proteins
  • 1.6.2 Principle of DNA Repair
  • Acknowledgements
  • References
  • Chapter 2 Photoinduced Dimerization in DNA: Singlet Excited State Reaction Paths 17
  • 2.1 Introduction
  • 2.2 Pyrimidine Dimers
  • 2.2.1 Mechanism of Thymine-Thymine Photodimerization
  • 2.2.2 Cytosine-Thymine
  • 2.3 Purine-Purine and Purine-Pyrimidine Dimers
  • 2.4 Concluding Remarks
  • Acknowledgements
  • References
  • Chapter 3 DNA Photoionization: From High to Low Energies 37
  • 3.1 Introduction
  • 3.2 Energies and Quantum Yields
  • 3.2.1 Direct High-energy Photoionization
  • 3.2.2 Indirect Low-energy Photoionization
  • 3.3 Nanosecond Flash Photolysis: Advantages and Limitations
  • 3.4 Evolution of Ejected Electrons
  • 3.5 Evolution of Purine Radicals
  • 3.5.1 Deprotonation and Tautomerization
  • 3.5.2 Radical Populations
  • 3.5.3 Reaction Dynamics
  • 3.6 Final Lesions
  • Acknowledgements
  • References
  • Chapter 4 Triplet Channel Photochemistry in DNA 55
  • 4.1 Introduction
  • 4.2 Formation of Nucleobase Triplet Excited State
  • 4.2.1 Intrinsic Population of Nucleobase Triplet Excited State
  • 4.2.2 Photosensitized Population of the Lowest Nucleobases Triplet Excited State
  • 4.2.3 Triplet-Triplet Energy Transfer Within the Helix
  • 4.3 Photoreactivity
  • 4.3.1 Cyclobutane Pyrimidine Dimers Formation
  • 4.3.2 Spore Photoproduct Formation
  • 4.3.3 Formation of (6-4) Photoproduct
  • 4.3.4 Reactivity from Upper Triplet Excited States
  • 4.4 Conclusion
  • References
  • Chapter 5 Tracking Excited Electronic States in DNA From Formation to Deactivation 77
  • 5.1 Introduction
  • 5.2 Excited States of DNA: Their Nature and Steady-state Spectra
  • 5.2.1 Electronic Absorption Spectra and Lineshapes
  • 5.2.2 Exciton Theory and Coupled Chromophores
  • 5.3 Excited States of DNA: Dynamic Properties
  • 5.3.1 Dynamics of Base Monomer Excited States
  • 5.3.2 Dynamics of DNA Strand Excited States
  • 5.3.3 Long-lived Intrastrand CT States
  • 5.3.4 Formation and Decay of CT States
  • 5.3.5 Excited-state Proton Transfer in Double Strands
  • 5.3.6 Conformational Dynamics and Excited State Dynamics
  • 5.4 Outlook
  • References

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