Multiple sclerosis /
"'Multiple Sclerosis' offers proven, effective treatments for specific presentations and symptoms of multiple sclerosis along with a pathophysiological explanation of why they work. It bridges a needed gap between overly simplistic therapy manuals and basic science texts that discuss...
| Autors principals: | , , |
|---|---|
| Format: | Licensed eBooks |
| Idioma: | anglès |
| Publicat: |
New York, NY :
Oxford University Press,
2013.
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| Col·lecció: | Contemporary neurology series ;
84. |
| Accés en línia: | https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=603953 |
Taula de continguts:
- Section 1: Pathogenesis
- Section 2: Treatment.
- The Spectrum and Diagnosis of Multiple Sclerosis. The spectrum of idiopathic inflammatory demyelinating diseases ; The diagnosis of prototypical multiple sclerosis ; The phases and evolution of prototypical multiple sclerosis ; Summary
- The Differential Diagnosis of Multiple Sclerosis. Other idiopathic inflammatory demyelinating diseases ; Neuro-myelitis optica spectrum disorders (Aquaporinopathies) ; Non-idiopathic inflammatory demyelinating diseases CNS syndromes that mimic multiple sclerosis ; Summary
- The Epidemiology of Multiple Sclerosis, Genetics, and Environment. Epidemiology of multiple sclerosis: A complex disease ; Genetics of multiple sclerosis ; Environmental risk factors in multiple sclerosis ; Summary
- The Role of Magnetic Resonance Imaging in Multiple Sclerosis. Introduction ; Conventional MRI in the clinic: Commonly used sequences and applications ; MRI in the diagnostic criteria of multiple sclerosis ; The role of MRI in prognosis of Clinically Isolated Syndrome ; Radiologically Isolated Syndrome ; The role of MRI in treatment decisions ; Special diagnostic considerations: MRI in tumefactive demyelination ; Advanced MRI techniques ; MRI in non-MS demyelinating diseases ; Summary
- Neuropathology: Clues to Pathogenesis. Traditional classification of inflammatory demyelinating pathology ; Neuropathology of MS: Established classification system ; New classification system ; Summary
- What Has Immunology Taught Us About Multiple Sclerosis? Introduction ; Fundamental question regarding the immunology of multiple sclerosis ; Is multiple sclerosis an autoimmune disease? ; Role of cytokines as surrogates for exacerbations or progression ; Role of chemokines in multiple sclerosis ; Role of proteinases in disease progression ; Persistent virus infection as a cause of multiple sclerosis? ; Natural killer cells ; CSF, IGG, and oligoclonal bands ; Immunoglobulins as a hindrance to oligodendrocyte progenitor differentiation and remyelination ; B cells as antigen-presenting cells ; Tears as a source of oligoclonal IGG in multiple sclerosis patients ; Role of CD4+ T cells as initiators of disease versus effectors in destruction of myelin ; Summary
- Neural Degeneration and Potential Novel Treatments. Introduction ; Axonal loss in normal-appearing white matter ; Relationship between axonal transection and inflammation ; Neuronal and axonal death ; Gray matter involvement in multiple sclerosis ; Biphasic disease: Inflammatory demyelination followed by axonal pathology ; Why do neurons and axons not regenerate in multiple sclerosis? ; Demyelination within deep gray matter structure ; What is the mechanism that injures axons and neurons? ; Does inflammation contribute to neuronal and axonal death? ; Lower motor neuron loss occurs in multiple sclerosis ; Summary
- Treatment of Acute Exacerbations of Multiple Sclerosis. Introduction ; Should all multiple sclerosis attacks be treated? ; Treatment modalities to address multiple sclerosis relapses: Steroids ; Treating steroid-unresponsive attacks: Plasmapheresis ; Treatment of fulminant multiple sclerosis attacks ; Summary
- Disease-Modifying Therapies in Multiple Sclerosis. Assessing magnitude of treatment effect ; Use of disease-modifying agents in Clinically Isolated Syndrome ; Altering the course of relapsing-remitting multiple sclerosis ; Altering the course of secondary progressive multiple sclerosis ; Therapy of primary progressive multiple sclerosis ; Summary
- Managing Symptoms of Multiple Sclerosis. The interactive matrix of symptomatic multiple sclerosis therapy ; The core of symptomatic multiple sclerosis therapy ; Motor disability ; Pain and paroxysmal symptom-related disability ; Autonomic disability ; Cognitive and behavioral disability ; Summary
- Future Disease-Modifying Treatment Approaches in Multiple Sclerosis. Current treatment outlook ; Anticipated clinical trials ; Summary
- Treatment to Promote Remyelination. Morphological features of CNS remyelination ; Oligodendrocyte remyelination in multiple sclerosis ; Schwann cell remyelination in multiple sclerosis ; Experimental models of remyelination ; Role of inflammation in remyelination ; Cellular basis of remyelination ; Why does remyelination fail in multiple sclerosis? ; Can the immune system be harnessed to enhance remyelination? ; Summary.