Health implications of perchlorate ingestion /

Perchlorate a powerful oxidant used in solid rocket fuels by the military and aerospace industry has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by...

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Dettagli Bibliografici
Ente Autore: National Research Council (U.S.). Division of Earth Sciences
Natura: Licensed eBooks
Lingua:inglese
Pubblicazione: Washington, D.C. : National Academies Press, ©2005.
Accesso online:https://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&AN=131245
Sommario:
  • Summary
  • 1. Introduction
  • 2. The thyroid and disruption of thyroid function in humans
  • 3. Epidemiologic studies of occupational and environmental exposures to perchlorate
  • 4. Animal studies
  • 5. Risk characterization of perchlorate
  • 6. Research recommendations
  • Appendix A. Biographic information on the Committee to Assess the Health Implications of Perchlorate Ingestion
  • Appendix B. Glossary
  • Appendix C. Participants at public sessions
  • Appendix D. Sensitivity of perchlorate-induced iodide uptake inhibition to serum iodide concentrations
  • Appendix E. Physiologically based pharmacokinetic modeling.