TY  - GEN
T1  - Health implications of perchlorate ingestion
LA  - English
PP  - Washington, D.C.
PB  - National Academies Press
YR  - 2005
UL  - https://ebooks.jgu.edu.in/Record/ebsco_acadsubs_ocm60193658
AB  - Perchlorate a powerful oxidant used in solid rocket fuels by the military and aerospace industry has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA). The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA s basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weight an amount more than 20 times the reference dose proposed by EPA should not threaten the health of even the most sensitive populations.
OP  - 260
CN  - TD427.P33 H43 2005eb
SN  - 030954811X
SN  - 9780309548113
SN  - 0309181356
SN  - 9780309181358
SN  - 1280173637
SN  - 9781280173639
SN  - 9786610173631
SN  - 661017363X
SN  - 0309095689
SN  - 9780309095686
KW  - Perchlorates : Physiological effect.
KW  - Drinking water : Contamination.
KW  - Rats.
KW  - Risk assessment.
KW  - Water-supply.
KW  - Human beings.
KW  - Animals
KW  - Humans
KW  - Rats
KW  - Perchloric Acid : adverse effects
KW  - Thyroid Gland : physiology
KW  - Environmental Exposure
KW  - Risk Assessment
KW  - Water Supply
KW  - United States
KW  - Perchlorates : Effets physiologiques.
KW  - Eau potable : Contamination.
KW  - Exposition (Toxicologie)
KW  - Évaluation du risque.
KW  - Eau : Approvisionnement.
KW  - Êtres humains.
KW  - risk assessment.
KW  - Homo sapiens (species)
KW  - POLITICAL SCIENCE : Political Freedom & Security : Law Enforcement.
KW  - Water-supply
KW  - Risk assessment
KW  - Drinking water : Contamination
ER  -