TY  - GEN
T1  - Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions
A2  - David Bikle, Daniel
LA  - eng
PB  - Frontiers Media SA
YR  - 2021
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-73730
AB  - There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.
SN  - 9782889635788
KW  - vitamin D binding protein
KW  - total 25-hydroxyvitamin D
KW  - free 25-hydroxyvitamin D
KW  - 1
KW  - 25-dihydroxyvitamin D
KW  - bioavailable 25-hydroxyvitamin D
KW  - thema EDItEUR::M Medicine and Nursing
KW  - thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJG Endocrinology
ER  -