TY  - GEN
T1  - Biomarkers of Environmental Toxicants
A2  - LU, Kun
LA  - eng
PB  - MDPI - Multidisciplinary Digital Publishing Institute
YR  - 2021
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-69154
AB  - Biomarkers of environmental toxicants are measures of exposures, some of which can serve to assess disease risk and inter-individual susceptibilities. Metabolites, protein and DNA adducts also serve to elucidate the mechanisms of the bioactivation and detoxication of reactive toxicant intermediates. Some environmental chemicals act as modulators of gene and protein activity, and induce the dysbiosis of the microbiome, which impacts the metabolome and overall health. In this Special Issue on “Biomarkers of Environmental Toxicants”, review articles and original research studies are featured, covering the latest bioanalytical, biochemical and mass spectrometry-based technologies, to monitor exposures through targeted and non-targeted methods, and mechanistic studies that examine the biological effects of environmental toxicants in cells and humans. Diverse topics, such as exposome, microbiome, DNA/protein adducts and t-RNA modifications, as well as important environment toxicants, including heavy metals, benzene, phthalates, aldehydes, glycidol, tobacco smoke and aristolochic acids, are covered. Novel analytical methods, such as protein adductomics, DNA adduct analysis in formalin-fixed paraffin-embedded tissues, site-specific mutagenesis assay and accelerator mass spectrometry, are also included. This collection provides a valuable update of the most recent biochemical and analytical tools that employ biomarkers in toxicology research, biomarker discovery, and exposure and risk assessment in population-based studies.
SN  - 9783039367368
SN  - 9783039367375
KW  - manganese
KW  - lead
KW  - cadmium
KW  - arsenic
KW  - hair
KW  - children
KW  - environment
KW  - carcinogen
KW  - DNA adducts
KW  - biomonitoring
KW  - formalin-fixed paraffin-embedded tissues
KW  - biomarker
KW  - mass spectrometry
KW  - human biomonitoring
KW  - urine
KW  - non-occupational exposure
KW  - S-phenyl-mercapturic acid
KW  - HPLC-MS/MS
KW  - glycidol
KW  - Hb adduct
KW  - N-(2.3-dihydroxypropyl)valine
KW  - in vivo
KW  - cancer risk
KW  - UPLC/MS/MS
KW  - aristolochic acids
KW  - food contamination
KW  - environmental pollution
KW  - root uptake
KW  - aristolochic acid nephropathy
KW  - Balkan endemic nephropathy
KW  - chronic kidney disease
KW  - tobacco smoke
KW  - human carcinogen
KW  - biomarkers
KW  - epitranscriptomics
KW  - tRNA modifications
KW  - stress response mechanisms
KW  - codon-biased translation
KW  - phthalate
KW  - DEHP
KW  - human exposure
KW  - toxicity
KW  - reproductive
KW  - accelerator mass spectrometry
KW  - cavity ring down spectrophotometry
KW  - radiocarbon
KW  - naphthalene
KW  - benzo[a]pyrene
KW  - cell turnover
KW  - triclocarban
KW  - metastasis
KW  - haemoglobin
KW  - albumin
KW  - protein adducts
KW  - aldehydes
KW  - genotoxicity
KW  - cancer
KW  - diseases
KW  - oxidative stress
KW  - exposure biomarkers
KW  - high-resolution mass spectrometry
KW  - data-dependent profiling
KW  - derivatization
KW  - biological fluids
KW  - isotope labeling
KW  - DNA lesion
KW  - DNA damage
KW  - shuttle vector technique
KW  - replication block
KW  - mutagenicity
KW  - mutational spectrum
KW  - mutational signature
KW  - DNA repair
KW  - DNA adduct bypass
KW  - site-specific mutagenesis
KW  - chemical exposome
KW  - environmental monitoring
KW  - disease
KW  - bioinformatics
KW  - gut microbiome
KW  - chemical toxicity
KW  - n/a
KW  - thema EDItEUR::M Medicine and Nursing
ER  -