TY  - GEN
T1  - Metastatic Progression and Tumour Heterogeneity
A2  - Hollande, Fred
LA  - eng
PB  - MDPI - Multidisciplinary Digital Publishing Institute
YR  - 2021
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-68966
AB  - Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.
SN  - 9783039288533
SN  - 9783039288540
KW  - clear cell renal cell carcinoma
KW  - tumor evolution
KW  - tumor ecology
KW  - intratumor heterogeneity
KW  - multisite tumor sampling
KW  - targeted therapy
KW  - uterine carcinosarcoma
KW  - endometrial carcinoma
KW  - metaplastic carcinoma
KW  - epithelial-to-mesenchymal transition
KW  - clonality
KW  - mutation
KW  - TP53
KW  - PI3K/AKT pathway
KW  - gene expression
KW  - miRNA expression
KW  - tumor microenvironment
KW  - interstitial pH
KW  - acidosis
KW  - tumor heterogeneity
KW  - magnetic resonance imaging
KW  - hyperpolarized 13C MRI
KW  - carbonic anhydrase
KW  - lactic acid
KW  - positron emission tomography
KW  - esophageal squamous cell carcinoma
KW  - precision medicine
KW  - natural killer cells
KW  - tumor mutation burden
KW  - immunotherapy
KW  - PET
KW  - heterogeneity
KW  - radiomics
KW  - radiopharmaceuticals
KW  - SUV
KW  - nuclear medicine
KW  - colon cancer
KW  - Wnt signaling
KW  - phenotypic plasticity
KW  - EMT
KW  - hybrid E/M
KW  - collective and single-cell migration
KW  - beta-catenin paradox
KW  - breast cancer
KW  - immune microenvironment
KW  - DCIS
KW  - ADH
KW  - mammary gland
KW  - cell fate
KW  - 3D cultures
KW  - organoids
KW  - signaling
KW  - single-cell RNAseq
KW  - tumor endothelial cell
KW  - metastasis
KW  - angiocrine factor
KW  - microsatellite instability
KW  - colorectal cancer
KW  - immune checkpoints
KW  - deficient mismatch repair
KW  - plasticity
KW  - biomechanics
KW  - circulating tumor cells (CTCs)
KW  - extracellular vesicles
KW  - metastatic niche
KW  - epigenetics
KW  - CTC-clusters
KW  - single-cell analysis
KW  - cellular heterogeneity
KW  - circulating tumor cells
KW  - pancreatic cancer
KW  - epithelial mesenchymal plasticity
KW  - target discovery
KW  - review
KW  - genomics
KW  - intra-tumour heterogeneity
KW  - subclonal diversity
KW  - treatment resistance
KW  - thema EDItEUR::M Medicine and Nursing
ER  -