TY  - GEN
T1  - Novel Pharmacological Inhibitors for Bacterial Protein Toxins
A1  - Holger Barth
LA  - eng
PB  - MDPI - Multidisciplinary Digital Publishing Institute
YR  - 2021
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-54883
AB  - Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action of bacterial toxins should prevent or cure the respective toxin-associated disease. Toxin inhibitors might be beneficial when the toxin acts in the absence of the producing bacteria (e.g., food poisoning), but also in combination with antibiotics in infectious diseases when the toxin-producing bacteria are present. The focus of this Special Issue of Toxins is on the development and characterization of novel inhibitors against bacterial toxins, e.g., toxin neutralizing antibodies, peptides or small compounds, as well as toxin pore blockers, which interfere with bacterial toxins and thereby protect cells from intoxication.
SN  - 9783038424307
SN  - 9783038424314
KW  - QH301-705.5
KW  - RA1190-1270
KW  - Bacterial AB-toxins
KW  - infection
KW  - Shiga toxin
KW  - semicarbazone EGA
KW  - pore-forming toxins
KW  - Botulinum Neurotoxin (BoNT)
KW  - black lipid bilayer membrane
KW  - cellular uptake
KW  - intracellular transport
KW  - anthrax toxins
KW  - Clostridium perfringens toxins
KW  - Diphtheria toxin
KW  - Clostridium difficile toxins
KW  - pore-blockers
KW  - sialidases
KW  - translocation
KW  - binary clostridial actin ADP-ribosylating toxins
KW  - dendrimers
KW  - clostridial toxins
KW  - food-poisoning
KW  - anti-toxins
KW  - intestinal pathogenesis
KW  - pharmacological inhibitors
KW  - membrane transport
KW  - probiotic microorganisms
KW  - thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
ER  -