TY  - GEN
T1  - Toxins
A2  - Ladant, Daniel
LA  - eng
PB  - MDPI - Multidisciplinary Digital Publishing Institute
YR  - 2023
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-100014
AB  - Toxins are biologically active substances produced by most kinds of living organisms, bacteria, fungi, plants, and animals. They present a vast diversity of molecular structures and target a wide variety of receptors involved in a range of physiological processes. As toxins are selected during evolution to acquire/improve their disabling/lethal effects, they display finely tuned functional properties often associated with high affinities and selectivity. Moreover, toxins are valuable tools to unravel cellular processes due to their extreme specificity for cell surface and/or intracellular targets. Therefore, toxins are very attractive compounds because of their Janus-like character; while they mostly act as deadly poisons like monstrous Mr. Hyde, they can also be tamed into good remedies like admirable Dr. Jekyll. As such, they have been primarily investigated not only for the light they can throw on fundamental physiological processes but also for their potential therapeutic applications. This reprint, emerging from the 27th Annual Meeting of the French Society of Toxinology (SFET, http://sfet.asso.fr/international), will be of great interest for those in the scientific community who want to know more about the fascinating world of toxins.
SN  - 9783036569048
SN  - 9783036569055
KW  - toxins
KW  - peptide chemistry
KW  - native chemical ligation
KW  - α-bungarotoxin
KW  - click chemistry
KW  - automated patch-clamp
KW  - fluorescent peptide
KW  - TE671 cells
KW  - nicotinic acetylcholine receptor
KW  - animal toxin
KW  - bacterial toxin
KW  - marine toxin
KW  - medical application
KW  - plant toxin
KW  - toxin function/activity
KW  - toxin receptor/target
KW  - toxin structure
KW  - Debaryomyces hansenii
KW  - Wickerhamomyces anomalus
KW  - Saccharomyces cerevisiae
KW  - PDR transporters
KW  - killer toxin
KW  - fetal adrenomedullary chromaffin cell
KW  - gambierol
KW  - potassium currents
KW  - calcium-activated K+ channels
KW  - ATP-sensitive K+ channels
KW  - catecholamine release
KW  - Clostridium tetani
KW  - Clostridium botulinum
KW  - botulinum neurotoxin
KW  - tetanus neurotoxin
KW  - toxin gene regulation
KW  - two-component system
KW  - small RNA
KW  - adenylate cyclase toxin
KW  - Bordetella pertussis
KW  - cyclic nucleotide
KW  - cAMP
KW  - spectrophotometric enzymatic assay
KW  - ASIC
KW  - sodium channels
KW  - peptide
KW  - PcTx1
KW  - APETx2
KW  - MitTx
KW  - mambalgin
KW  - pain
KW  - nociception
KW  - clostridial C3 toxin
KW  - C3bot
KW  - C3botE174Q
KW  - dendritic cells
KW  - macrophages
KW  - monocytes
KW  - stimulated emission depletion (STED)
KW  - super-resolution microscopy
KW  - trained immunity
KW  - effector-triggered immunity
KW  - effector-triggered trained immunity
KW  - staphylococcal superantigen
KW  - enterotoxin
KW  - toxin pathogenicity
KW  - immunomodulation
KW  - molecular and cellular targets
KW  - n/a
KW  - thema EDItEUR::M Medicine and Nursing
KW  - thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology::MKGT Medical toxicology
ER  -