TY  - GEN
T1  - Genetic and Epigenetic Regulations of Tumor Progression and Metastasis
A2  - Smolkova, Bozena
LA  - eng
PB  - MDPI - Multidisciplinary Digital Publishing Institute
YR  - 2023
UL  - https://ebooks.jgu.edu.in/Record/doab-20.500.12854-100008
AB  - Genetic aberrations and epigenetic modifications are critical drivers of cancer progression and metastasis. Although recurrent mutations in primary and metastatic cancers have been shown to be concordant, there are several metastasis-associated mutations responsible for resistance to specific therapies that are frequently located in genes that regulate DNA methylation and chromatin modifications. Recent studies have shown that distinct subgroups of poor-prognosis tumors lack genetic alterations but are epigenetically regulated, pointing to the critical role of epigenetic modifications in cancer progression. This Special Issue provides novel insights into the mechanisms underlying processes associated with cancer cell plasticity and the development of metastatic disease.
SN  - 9783036571850
SN  - 9783036571843
KW  - prostate cancer
KW  - metastasis
KW  - epithelial-to-mesenchymal transition (EMT)
KW  - partial-EMT (p-EMT)
KW  - Zeb1
KW  - DNA methylation
KW  - 5-azacytidine
KW  - lung adenocarcinoma
KW  - brain metastasis
KW  - omics data analysis
KW  - CDKN2A
KW  - p16
KW  - invasive ductal breast cancer
KW  - CDH1 gene
KW  - EMT genes
KW  - miRNA and mRNA expression
KW  - E-cadherin
KW  - HTR2B
KW  - STAT proteins
KW  - uveal melanoma
KW  - promoter
KW  - gene transcription
KW  - PDAC
KW  - inflammation
KW  - hypoxia
KW  - epithelial-to-mesenchymal transition
KW  - cancer proliferation
KW  - hepatocellular carcinoma
KW  - engineered exosomes
KW  - diagnostic biomarker
KW  - cancer therapy
KW  - angiogenesis
KW  - pericytes
KW  - adipose tissue
KW  - cell adhesion
KW  - endothelial cells
KW  - breast cancer
KW  - metastatic cascade
KW  - intra-tumor heterogeneity
KW  - mutational profile
KW  - adaptive responses
KW  - autophagy
KW  - tumor mutational burden
KW  - tumor microenvironment
KW  - waterpipe smoke
KW  - lung cancer
KW  - n/a
KW  - CYSLTR1
KW  - CYSLTR2
KW  - methylation
KW  - prognosis
KW  - colorectal cancer
KW  - EMT
KW  - thema EDItEUR::M Medicine and Nursing
KW  - thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCL Oncology
ER  -